These are the Billboard Hot 100 number-one singles of 1980. The two longest running number-one singles of 1980 are "Call Me" by Blondie and "Lady" by Kenny Rogers with each single obtaining six weeks on top of the chart.
| Issue Date | Song | Artist(s) | Reference |
|---|---|---|---|
| January 5 | "Please Don't Go" | KC and the Sunshine Band | |
| January 12 | "Escape (The Piña Colada Song)" | Rupert Holmes | |
| January 19 | "Rock with You" | Michael Jackson | |
| January 26 | |||
| February 2 | |||
| February 9 | |||
| February 16 | "Do That to Me One More Time" | Captain & Tennille | |
| February 23 | "Crazy Little Thing Called Love" | Queen | |
| March 1 | |||
| March 8 | |||
| March 15 | |||
| March 22 | "Another Brick in the Wall, Part II" | Pink Floyd | |
| March 29 | |||
| April 5 | |||
| April 12 | |||
| April 19 | "Call Me" | Blondie | |
| April 26 | |||
| May 3 | |||
| May 10 | |||
| May 17 | |||
| May 24 | |||
| May 31 | "Funkytown" | Lipps Inc | |
| June 7 | |||
| June 14 | |||
| June 21 | |||
| June 28 | "Coming Up" | Paul McCartney | |
| July 5 | |||
| July 12 | |||
| July 19 | "It's Still Rock and Roll to Me" | Billy Joel | |
| July 26 | |||
| August 2 | "Magic" | Olivia Newton-John | |
| August 9 | |||
| August 16 | |||
| August 23 | |||
| August 30 | "Sailing" | Christopher Cross | |
| September 6 | "Upside Down" | Diana Ross | |
| September 13 | |||
| September 20 | |||
| September 27 | |||
| October 4 | "Another One Bites the Dust" | Queen | |
| October 11 | |||
| October 18 | |||
| October 25 | "Woman in Love" | Barbra Streisand | |
| November 1 | |||
| November 8 | |||
| November 15 | "Lady" | Kenny Rogers | |
| November 22 | |||
| November 29 | |||
| December 6 | |||
| December 13 | |||
| December 20 | |||
| December 27 | "(Just Like) Starting Over" | John Lennon |
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